Epidemiological characteristics and influencing factors of Blastocystis hominis infection among children with diarrhea under five years of age in Guangzhou City
10.16250/j.32.1374.2022140
- VernacularTitle:广州市5岁以下腹泻儿童人芽囊原虫感染流行病学 特征及影响因素
- Author:
Wei-rong XU
1
;
Guo-shu WANG
1
;
Qin LI
2
;
Jin-xin ZHENG
2
;
Zhao-yu GUO
2
;
Jia-xu CHEN
2
;
Mu-xin CHEN
2
;
Li-guang TIAN
2
Author Information
1. Institute of Disease Control and Prevention of China Railway Qinghai-Aibet Group Co., Ltd., Xining, Qinghai 810007, China; Co-first authors
2. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Aropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, School of Global Health, National Center for International Research on Aropical Diseases and Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
Blastocystis hominis;
Epidemiological characteristic;
Influencing factor;
Diarrhea;
Children;
Guangzhou City
- From:
Chinese Journal of Schistosomiasis Control
2022;34(6):598-603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and influencing factors of Blastocystis hominis infection among children with diarrhea under five years of age in Guangzhou City. Methods Children with diarrhea under 5 years of age admitted to Guangzhou Children’s hospital, Guangzhou Maternity and Child Healthcare Hospital and Guangzhou Women and Children’s Medical Center during the period between January 1 and December 31, 2020, were enrolled. Participants’ demographics, living environments and health status were collected using questionnaire surveys. Stool samples were collected from participants and nucleic acid was extracted. B. hominis infection was identified using PCR assay and sequence alignment, and the factors affecting B. hominis infection among children with diarrhea under 5 years of age were identified using univariate analysis and multivariate logistic regression analysis. Results A total of 684 children with diarrhea under 5 years of age were enrolled, including 468 male children and 216 female children, with a mean age of (1.79 ± 1.12) years. The overall prevalence of B. hominis infection was 4.97% [34/684, 95% confidential interval (CI): (3.59%, 6.86%)] among participants, and there was no significant difference in the prevalence of B. hominis infection between children with chronic [7.52% (20/266), 95% CI: (4.92%, 11.33%)] and acute diarrhea [3.35% (14/418), 95% CI: (2.01%, 5.54%)] (χ2 = 5.983, P = 0.014). Multivariate logistic regression analysis identified keeping pet [odds ratio (OR) = 6.298, 95% CI: (2.711, 14.633)], drinking non-tap water [OR = 4.522, 95% CI: (1.769, 11.561)], lactose intolerance [OR = 4.221, 95% CI: (1.043, 17.087)], antibiotic use [OR = 0.125, 95% CI: (0.017, 0.944)] and chronic diarrhea [OR = 2.172, 95% CI: (1.018, 4.637)] as factors affecting B. hominis infection among children with diarrhea under 5 years of age in Guangzhou City. Conclusions B. hominis infections is detected in children with diarrhea under five years of age in Guangzhou City. Improving home environments and pet-keeping hygiene is recommended to reduce the likelihood of B. hominis infection among children.
