Research progress on the effect mechanism of polysaccharides against pancreatic cancer
- VernacularTitle:多糖类成分抗胰腺癌作用机制的研究进展
- Author:
Guangyu LIU
1
;
Qi WANG
2
;
Ling SU
3
Author Information
1. Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi，Jilin Agricultural University，Changchun 130118，China;College of Chinese Materia Medica，Jilin Agricultural University，Changchun 130118，China
2. Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi，Jilin Agricultural University，Changchun 130118，China;College of Plant Protection，Jilin Agricultural University，Changchun 130118，China
3. Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi，Jilin Agricultural University，Changchun 130118，China
- Publication Type:Journal Article
- Keywords:
polysaccharide;
pancreatic cancer;
effect mechanism
- From:
China Pharmacy
2023;34(1):111-116
- CountryChina
- Language:Chinese
-
Abstract:
Polysaccharide is a recognized immunomodulator that has been shown to have inhibitory effects on a variety of cancer cells and has the potential to be developed as an anti-cancer drug. Pancreatic cancer， one of the cancers with the highest mortality rate， is treated with long-term chemotherapeutic drugs and is prone to a variety of side effects such as immune deficiency， fatigue， and neurological lesions. The polysaccharide anti-pancreatic cancer research landscape both domestically and internationally is summarized in this publication. By regulating nuclear factor-κB， Hippo-Yes-associated protein， integrin and other signaling pathways， polysaccharide components play an anti-pancreatic cancer role by multi-target ways， such as inducing apoptosis and autophagy， inhibiting proliferation， migration and invasion of cancer cells， and regulating the cancer cell cycle.
