Prevalence and risk factors of medication non-adherence in children with inflammatory bowel disease.
10.3760/cma.j.cn112140-20220110-00036
- VernacularTitle:炎症性肠病患儿服药依从性现状及风险因素研究
- Author:
Yuan Yuan WU
1
;
You You LUO
2
;
Ling Fei HUANG
1
;
Hui Juan WANG
1
;
Xiang Bo GAO
1
;
Jin SUN
1
;
Jie CHEN
2
Author Information
1. Department of Pharmacy, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310051, China.
2. Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310051, China.
- Publication Type:Journal Article
- MeSH:
Male;
Female;
Child;
Humans;
Infant, Newborn;
Infant;
Child, Preschool;
Cross-Sectional Studies;
Prevalence;
Inflammatory Bowel Diseases/epidemiology*;
Medication Adherence;
Chronic Disease;
Risk Factors
- From:
Chinese Journal of Pediatrics
2022;60(11):1191-1195
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prevalence and risk factors of medication non-adherence in children with inflammatory bowel disease (IBD). Methods: A cross-sectional study was conducted in Children's Hospital, Zhejiang University School of Medicine from September 2020 to March 2022 and 112 children with IBD were enrolled. Their general information, medication adherence, and parental disease-related knowledge were collected by questionnaires. According to the medication adherence score, the children were divided into the adherence group (score of 6 to 8) and the non-adherence group (score of <6), then the demographic and clinical characteristics of the two groups were compared. Subsequently, a multivariate binary Logistic regression analysis was performed to determine the risk factors of medication non-adherence. Results: Of the 112 children, 76 were males and 36 females, with the age of 12.9 (9.5, 14.0) years. There were 50 (44.6%) in the non-adherence group and 62 (55.4%) in the adherence group. Regarding the demographic and clinical characteristics, the results showed that the dosage frequency and the parental disease related knowledge were associated with medication non-adherence (both P<0.05). Multivariate binary Logistic regression analysis showed that compared with 0-6 years old children, the risk of medication non-adherence was significantly increased in children aged 7-12 years (OR=9.30, 95%CI 1.58-54.87, P=0.014) and 13-18 years (OR=8.26, 95%CI 1.49-45.85, P=0.016); and the risk was also significantly increased in children who took medication twice or more per day (OR=12.88, 95%CI 2.77-59.80, P=0.001) compared with children who took medication once per day. Meanwhile, the parental score of the questionnaire on Crohn's disease and ulcerative colitis related knowledge (OR=0.76, 95%CI 0.66-0.89, P=0.001) was also a significant risk factor. Conclusions: Medication non-adherence is common in children with IBD. Children older than 7 years, a dosage frequency of twice or more per day, and parental poor disease-related knowledge are the independent risk factors for medication non-adherence in children with IBD. Clinicians should pay attention to promoting patients' adherence to improve clinical outcomes.
