Clinicopathological Analysis of Parathyroid Lesions in Fine-needle Aspiration Cytology
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2022.0620
- VernacularTitle:甲状旁腺病变细针穿刺标本的临床病理分析
- Author:
Hai-feng LI
1
;
Yan-ying JI
1
;
Lu ZHOU
1
;
Jian-ning CHEN
1
Author Information
1. Department of Pathology， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630，China
- Publication Type:Journal Article
- Keywords:
parathyroid lesions;
diagnostic pitfall and challenge;
fine-needle aspiration;
cytology
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(6):1035-1040
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinicopathological characteristics of parathyroid lesions in fine-needle aspiration cytology. MethodsThe clinical and pathological features of 12 cases of parathyroid lesions in fine-needle aspiration cytology in our hospital were retrospectively analyzed. ResultsThere are 6 males and 6 females， with the median age of 47 years （39.25~ 63.25 years）. Ultrasound results demonstrated that the majority of cases were solid nodules with clear boundary and uneven internal echoes. Liquid-based cytology showed that the cellularity ranged from minimal to abundant. The majority of cases showed small and round cells with finely or coarsely granular （salt and pepper） chromatin. The cytoplasm of parathyroid cells was moderate to scant， and had indistinct cytoplasmic border. The architectural patterns included small cluster， small follicular， trabecular， small flake or large flake， the boundary of large cell groups was generally fuzzy. All twelve samples were positive for parathyroid hormone （PTH） and negative for thyroglobulin （TG） on cell blocks. ConclusionsParathyroid lesions in fine-needle aspiration cytology are rare and pose a diagnostic challenge. When cells arranged in small clusters or trabecular on liquid-based smears， and the cells were small and round with finely or coarsely granular （salt and pepper） chromatin， pathologists should be aware of the possibility of parathyroid lesions. PTH positivity and TG negativity on cell blocks is helpful in confirming the diagnosis in this instance.
