Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice

Author: Lin CHEN ¹ ; Shu-Yu REN ¹ ; Rui-Xue LI ¹ ; Kun LIU ¹ ; Jing-Fei CHEN ¹ ; Yu-Jian YANG ¹ ; Han-Zhi WANG ¹ ; Lan XIAO ¹ ; Feng MEI ¹ ; Fei WANG ¹ ; Yong-Bin DENG ²
Author Information

1. Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University
2. Department of Neurosurgery, Chongqing Emergency Medical Center, Chongqing University
Publication Type:Journal Article
Keywords: Chronic hypoxia; Clemastine; Myelinogenesis; Neuro-function impairment; White matter
From: Neuroscience Bulletin 2021;37(10):1397-1411
CountryChina
Language:Chinese
Abstract: Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths (NG2-CreER