Effect of ulinastatin combined rivaroxaban on deep vein thrombosis in major orthopedic surgery
10.1016/S1995-7645(14)60162-0
- Author:
Xi YU
1
;
Guo-Yi LV
1
;
Xi YU
2
;
Yi TIAN
2
;
Ka WANG
2
;
Ying-Lin WANG
2
;
Guo-Gang TIAN
2
Author Information
1. Department of Anesthesiology, 2nd hospital of Tianjin Medical University
2. Department of Anesthesiology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital
- Publication Type:Journal Article
- Keywords:
DVT;
Orthopedic surgery;
Rivaroxaban;
Ulinastatin
- From:
Asian Pacific Journal of Tropical Medicine
2014;7(11):918-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of ulinastatin (UTI) continuous infusion combined Rivaroxaban on the deep vein thrombosis in patients undergoing major orthopedic surgery. Methods: Forty-five patients undergoing major orthopedic surgery were randomly divided into three groups:ulinastatin continuous infusion (Uc) group, ulinastatin single injection (Us) group and control (C) group. All patients received patient-controlled intravenous analgesia (PCIA) after operation, and took Rivaroxaban 10 mg orally 12 hours after operation. Ulinastatin (5 000 U/kg) was given intravenously to both Uc and Us groups preoperatively. Group C was given isometric normal saline, group Uc was pumped UTI continuous intravenously at the end of surgery (10 000 U/kg) to 48 hours through PCIA pump. The values of hematocrit (HCT), thrombomodulin (TM), Interleukin (IL-6), thrombin-antithrombin complex (TAT), D-Dimer (D-D) were normally tested before surgery (T1), at the end of the surgery (T2), 12 hours (T3), 24 hours (T4) and 48 hours (T5) after surgery. Results: Compared with T1, there was an upward tendency in TM, IL-6, TAT, and D-D after operation in group C group (. P<0.05). The values of them were significantly increased from nearly 24-hour after surgery in Us group (. P<0.05). In group Uc, there were no significant changes in these indices after operation (. P>0.05). Conclusions: During the perioperative period, ulinastatin continuous infusion combined Rivaroxaban can correct blood hypercoagulability through different approaches in patients undergoing major orthopedic surgery.
