Changes of TIZ expression in epithelial ovarian cancer cells
10.1016/S1995-7645(14)60308-4
- Author:
Huan-Yu ZHENG
1
;
En-Ling LIU
1
;
Jie LI
1
;
Yan-Mei ZHANG
1
;
Hong-Yu ZHENG
2
;
Yun-Tao ZHOU
3
Author Information
1. Department of Obstetrics and Gynecology, Affiliated Tangshan Workers Hospital of Hebei Medical University
2. Department of Pharmacy, Tangshan People's Hospital
3. Central Laboratory, Affiliated Tangshan Workers Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Cell proliferation;
Epithelial ovarian cancer cells;
Invasion ability;
TIZ expression
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(2):157-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the change of TIZ expression in epithelial ovarian cancer cells. Methods: HO8910 cells were transinfected with siRNA to inhibit the expression of TIZ. pcDNA3.1-TIZ vectors were combined to increase the TIZ expression level. The cell viability, colony forming efficiency and cycle distribution of HO8910, HO8910/NC, HO8910/pcDNA3.1-NC, HO8910/TIZ-573 and H08910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between 5 groups of cells were compared. Results: Compared with those of HO8910, HO8910/NC and HO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution of HO8910/TIZ-573 were increased, while the indexes of H08910/pcDNA3.1-NC were decreased with statistical significant difference (. P<0.05). There was no statistical significant difference in the invasion rate, migration rate and adhesion rate between 5 groups of cells (. P>0.05). Conclusions: The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.
