Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats
10.1016/j.apjtm.2015.11.006
- Author:
Zhen-Lv LIN
1
;
Guang-Wei ZHENG
1
;
Lin ZHANG
2
;
Jian-Tao ZHENG
2
;
Hui CHEN
2
Author Information
1. Department of Emergency Surgery, The First Affiliated Hospital of Fujian Medical University
2. Department of Gastroenterology, The First Affiliated Hospital of Fujian Medical University
- Publication Type:Journal Article
- Keywords:
Cytokine;
Gastric precancerous lesions;
Immune regulation;
Mesenchymal stem cells
- From:
Asian Pacific Journal of Tropical Medicine
2015;8(12):1060-1063
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change. Methods: The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of BMMSCs, the migration and colonization location was then observed, as well as its effect on the related factors of gastric precancerous lesions, including VEGF, IL-10 and IFN-γ Results: BMMSCs were mainly colonized in the gastric body and gastric antrum, which could be differentiated into the epithelial and interstitial cells. The expression of VEGF in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05); while the expression of VEGF in the transplantation group was significantly higher than that in the non-transplantation group (t = 3.88, P < 0.001). The expression of serum IL-10 and IFN-γ in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05), while the expression of IL-10 and IFN-γ in the transplantation group was significantly lower than that in the non-transplantation group (t = 3.03, P = 0.004; t = 3.80, P < 0.001). Conclusions: BMMSCs can be directionally differentiated into the epithelial and interstitial cells and can also regulate the related growth factors and inflammatory factors to reduce the injury of inflammation, relieve or reverse the process of gastric precancerous lesions.
