Effect of levocarnitine on TIMP-1, ICAM-1 expression of rats with coronary heart disease and its myocardial protection effect
10.1016/j.apjtm.2016.01.025
- Author:
Shi-Xun WANG
1
;
Jing-Quan ZHONG
1
;
Shi-Xun WANG
2
;
Lei TAN
2
;
Jian WANG
2
Author Information
1. Key Lab. of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health, State and Shandong Province Joint Key Lab., Translational Cardiovascular Medicine, Qilu Hospital of Shandong University
2. Department of Cardiology, Weifang People's Hospital
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
ICAM-1;
Levocarnitine;
TIMP-1
- From:
Asian Pacific Journal of Tropical Medicine
2016;9(3):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of levocarnitine (L-CN) on tissue inhibitor of metalloproteinase-1 (TIMP-1) and intercellular adhesion molecule-1 (ICAM-1) expression of rats with coronary heart disease and evaluate the protective effect of L-CN on myocardial cells. Methods: High-fat diet feeding and intraperitoneal injection of pituitrin was performed on rats in model group and CHD Model of rats was built. Rats with successful model-building were selected and divided into L-CN group and Ctrl group randomly. Rats in L-CN group were given L-CN treatment, with intraperitoneal injection of 200 mg·kg
