Zika virus infection, transmission, associated neurological disorders and birth abnormalities: A review of progress in research, priorities and knowledge gaps
10.1016/j.apjtb.2016.08.008
- Author:
Yitades GEBRE
1
;
Nikkiah FORBES
2
;
Teshome GEBRE
3
Author Information
1. Pan American Health Organization/World Health Organization, Country Office
2. National HIV/AIDS and Infectious Disease Programme, Ministry of Health
3. International Trachoma Initiative, the Task Force for Global Health
- Publication Type:Journal Article
- Keywords:
Guillain–Barré syndrome;
Microcephaly;
Vector;
Zika virus;
Zika virus research;
Zika virus transmission
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(10):815-824
- CountryChina
- Language:Chinese
-
Abstract:
On February 1, 2016, the World Health Organization declared that the cluster of microcephaly cases and other neurological disorders constitute public health emergency of international concern. Furthermore, few studies demonstrated that there was an increased evidence of causal relationship of Zika virus (ZIKAV) infection and microcephaly, birth abnormalities and neurological disorders such as Guillain–Barré syndrome. ZIKAV transmission occurs mainly by the bite of infected mosquitos (Aedes species), but there are also reports that infections could occur via the placenta, breast milk, saliva, blood transfusion and sex. This article reviews the global efforts, progress in scientific research to understand the pathogenesis of ZIKAV infection & disease, clinical presentations, congenital transmission and autoimmune neurological disorders. The paper further explores the knowledge gaps, future priority research agenda for strategic response including vector control and prevention. We conducted a systematic literature review to synthesise available evidence on ZIKAV infection and its vector and host interaction from electronic databases.
