Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum
10.1016/j.apjtb.2016.08.011
- Author:
Masteria Yunovilsa PUTRA
1
;
Tutik MURNIASIH
1
;
Joko Tri WIBOWO
1
;
Irma Shita ARLYZA
1
;
Respati Tri SWASONO
2
;
Annissa Nur Cahya SAPUTRI
2
;
Meilia Rahma WIDHIANA
2
Author Information
1. Research Center for Oceanography, Indonesian Institute of Sciences
2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada
- Publication Type:Journal Article
- Keywords:
Biological activities;
Indonesia;
Natural products;
Ocean
- From:Asian Pacific Journal of Tropical Biomedicine
2016;6(11):909-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp. Methods This organism was collected from the Selayar Islands (South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity. Results It was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC
