Plant extracts as natural photosensitizers in photodynamic therapy: in vitro activity against human mammary adenocarcinoma MCF-7 cells
10.1016/j.apjtb.2017.01.025
- Author:
Rigo Baluyot VILLACORTA
1
;
Sonia Donaldo JACINTO
1
;
Kristine Faith Javier ROQUE
2
;
Giovanni Alarkon TAPANG
2
Author Information
1. Institute of Biology, University of the Philippines
2. National Institute of Physics, University of the Philippines
- Publication Type:Journal Article
- Keywords:
Albizia procera;
Cananga odorata;
Lumnitzera racemosa;
MCF-7;
Photodynamic therapy;
Photosensitizer
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(4):358-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine three plant extracts [Lumnitzera racemosa (Combretaceae) (L. racemosa), Albizia procera (Fabaceae) (A. procera) and Cananga odorata (Annonaceae)] for their potential as source of photosensitizers in photodynamic therapy. Methods Human mammary adenocarcinoma (MCF-7) cells were treated with the plant extracts, which were irradiated with 5.53 mW and 0.553 mW broadband light. Cell viability was assessed using MTT assay and induction of apoptosis was determined using terminal deoxynucleotidyl transferase-dUTP nick end labeling assay. Results The crude ethanolic extracts, independently, were nontoxic against cancer and non-cancer cells but when irradiated with 5.53 mW broadband light, L. racemosa and A. procera extracts were cytotoxic against MCF-7 with IC
