Anti-acetylcholinesterase activity of the aglycones of phenolic glycosides isolated from Leonurus japonicus
10.1016/j.apjtb.2017.08.013
- Author:
Agung NUGROHO
1
;
Jae Sue CHOI
2
;
Joon-Pyo HONG
3
;
Hee-Juhn PARK
3
Author Information
1. Department of Agro-industrial Technology, Faculty of Agriculture, Lambung Mangkurat University
2. Department of Food Science and Nutrition, Pukyong National University
3. Department of Pharmaceutical Engineering, Sangji University
- Publication Type:Journal Article
- Keywords:
Acetylcholinesterase;
Caffeic acid;
Lamiaceae;
Leonurus japonicus;
Phenolic glycosides;
Quercetin
- From:Asian Pacific Journal of Tropical Biomedicine
2017;7(10):849-854
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the genuine structure with anti-acetylcholinesterase (anti-AChE) from the phenolic glycosides abundant in Leonurus japonicus (Lamiaceae). The assay for anti-AChE activity is often used to lead anti-Alzheimer's drugs. Methods The five phenolic glycosides, tiliroside, leonurusoside C, 2‴-syringoylrutin, rutin, and lavanduliofolioside were isolated from L. japonicus. The activities of the glycosides were relatively low. Seven compounds including p-coumaric acid, caffeic acid, hydroxytyrosol, salidroside, syringic acid, kaempferol, and quercetin, which are produced by the hydrolysis of the five glycosides, were also assayed for anti-AChE activity. Results Of those seven compounds, the five compounds other than salidroside and syringic acid exhibited potent anti-AChE activities. In particular, the IC
