Pharmacological aspects of fisetin

Author: Lucia Dwi ANTIKA ¹ ; Rita Marleta DEWI ²
Author Information

1. Research Center for Chemistry, Indonesian Institute of Sciences
2. Center for Research and Development for Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health
Publication Type:Journal Article
Keywords: Anti-diabetic; Anti-inflammatory; Anti-osteoporosis; Anticarcinogenic; Cardioprotective activity; Fisetin
From:Asian Pacific Journal of Tropical Biomedicine 2021;11(1):1-9
CountryChina
Language:Chinese
Abstract: Over the past decades, epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health. Fisetin (3,3',4',7-tetrahydroxyflavone) is a hydrophobic polyphenolic compound primarily found in edible plants (e.g. strawberry, blueberry, apple, grape, persimmon, kiwi, and cucumber). Various preclinical studies have revealed that fisetin exhibits a wide range of pharmacological effects such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-osteoporotic, antimicrobial, and anti-diabetic properties. Therefore, the pharmacological in vitro and in vivo studies on fisetin are discussed in this review. Additionally, this review would be useful for further study regarding the potential of natural products, notably fisetin, and its therapeutic potential for the prevention and treatment of diseases.