Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury.
10.1016/S1875-5364(22)60199-7
- Author:
Yi-Jie ZHANG
1
;
Ming BAI
1
;
Jia-Yi LI
1
;
Shu-Yan QIN
1
;
Yu-Yang LIU
1
;
Xiao-Xiao HUANG
1
;
Jiang ZHENG
2
;
Shao-Jiang SONG
3
,
4
Author Information
1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China. Electronic address: zhengneu@yahoo.com.
3. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: songsj99@
4. com.
- Publication Type:Journal Article
- Keywords:
Lauraceae;
Litsea lancilimba;
Neuroprotective effect;
Sesquiterpenoids
- MeSH:
Chromatography, Liquid;
Humans;
Hydrogen Peroxide/toxicity*;
Litsea;
Molecular Structure;
Neuroblastoma/drug therapy*;
Neuroprotective Agents/pharmacology*;
Sesquiterpenes/chemistry*;
Tandem Mass Spectrometry
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(9):701-711
- CountryChina
- Language:English
-
Abstract:
Five undescribed sesquiterpenoids (1-5), and nine known sesquiterpenoids (6-14) were obtained from the fruits of Litsea lancilimba Merr. by LC-MS/MS molecular networking strategies. Litsemene A (1) possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of guaiane. Their structures were elucidated by spectroscopic techniques including IR, UV, NMR, HR-ESI-MS, and their absolute configurations were assigned by ECD calculations. All isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H2O2-induced injury in human neuroblastoma SH-SY5Y cells.
