Review of classical prescriptions in treatment of ulcerative colitis.
10.19540/j.cnki.cjcmm.20220713.501
- Author:
Yong-Jian AI
1
;
Meng-Qi HE
1
;
Yi-Tao WANG
2
;
Qiong-Lin LIANG
1
Author Information
1. Institute of Traditional Chinese Medicine-X, State Administration of Traditional Chinese Medicine Third-level Laboratory of Traditional Chinese Medicine Chemistry, Chinese Medicine Modernization Research Center, Tsinghua University Beijing 100084, China.
2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078, China.
- Publication Type:Journal Article
- Keywords:
action mechanism;
classical prescription;
clinical application;
material basis;
quality control;
ulcerative colitis
- MeSH:
Animals;
Colitis, Ulcerative/drug therapy*;
Drugs, Chinese Herbal/pharmacology*;
Molecular Docking Simulation;
Gas Chromatography-Mass Spectrometry;
Medicine, Chinese Traditional;
Drug Prescriptions
- From:
China Journal of Chinese Materia Medica
2022;47(21):5797-5805
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC) is a continuous inflammatory bowel disease with the main clinical manifestations of abdominal pain, diarrhea, and mucous bloody stools, mainly attacking the colorectal mucosa and submucosa. It is characterized by high recurrence rate, difficult cure, and clustering and regional occurrence. Chinese medicinal prescriptions for the treatment of UC have good therapeutic effect, multi-target regulation, slight toxicity, and no obvious side effects. In particular, the classical prescriptions highlight the characteristics and advantages of traditional Chinese medicine theory and have attracted much attention in recent years. To enable researchers to timely and comprehensively understand the classical prescriptions in the treatment of UC, we reviewed the studies about the pharmacodynamic material basis, quality control, action mechanism, and clinical application of relevant classical prescriptions. We first introduced the latest research progress in the active components such as alkaloids, polysaccharides, saponins, and flavonoids in relevant classical prescriptions. Then, we reviewed the latest research achievements on the quality control of classical prescriptions for the treatment of UC by gas chromatography, liquid chromatography, mass spectrometry, liquid chromatography-mass spectrometry and the like. Further, we summarized the research advances in the mechanisms of relevant prescriptions in the treatment of UC based on network pharmacology, molecular docking, integrated pharmacology platform, and animal experiments. Finally, we generalized the clinical application of the classical prescriptions for clearing heat and removing dampness, mildly regulating cold and heat, soothing liver and regulating spleen, strengthening spleen and invigorating Qi, and tonifying spleen and stomach. By systematic summary of the research progress in relevant classical prescriptions, we hope to promote the application and development of such prescriptions in UC treatment.
