Mystery of Yiyin decoction theory: rule discovery and evaluation strategy of atypical pharmacological effects of Chinese medicinal prescription.
10.19540/j.cnki.cjcmm.20220713.601
- Author:
Ying DAI
1
;
Yi-Guan ZHANG
1
;
Jin ZENG
1
;
Hua HUA
1
;
Jun-Ning ZHAO
1
;
Li LI
1
;
Liang-Chun YAN
1
;
Zhu-Jun YIN
1
;
Jian-Bo WANG
1
;
Peng TAN
1
;
Rui-Rong TAN
1
;
An-Qi ZENG
1
;
Yun-Yun QUAN
1
;
Ping WEI
1
Author Information
1. Sichuan Institute for Translational Chinese Medicine,Sichuan Academy of Chinese Medical Sciences,Key Laboratory of Biological Evaluation of Traditional Chinese Medicine Quality of National Administration of Traditional Chinese Medicine,Translational Chinese Medicine Key Laboratory of Sichuan Province,Sichuan Engineering Research Center for Authentic Medicine Formation Principle and Quality Evaluation,Sichuan Engineering Research Center for Authentic Medicine System Development Chengdu 610041,China.
- Publication Type:Journal Article
- Keywords:
Chinese medicinal prescriptions;
Yiyin decoction theory;
atypical pharmacological effects;
magic bullet theory;
moderate regulation;
multi-target therapeutic effect
- MeSH:
China;
Drugs, Chinese Herbal/pharmacology*;
Medicine, Chinese Traditional;
Prescriptions
- From:
China Journal of Chinese Materia Medica
2022;47(16):4261-4268
- CountryChina
- Language:Chinese
-
Abstract:
Yi Yin, a famous medical scientist and culinary master in the late Xia Dynasty and early Shang Dynasty, developed the Chinese medicinal liquids and Chinese medicinal prescriptions emerged after that. Chinese medicinal prescriptions have attracted much attention because of their unique advantages in the treatment of chronic multifactorial diseases, representing an important direction of drug discovery in the future. Yiyin decoction theory is the superior form of personalized combined medication with advanced consciousness. It is different from not only the magic bullet theory of single component action but also the connotation of modern multi-target drugs. The core of Yiyin decoction theory can be summarized as compound compatibility, multiple effects, and moderate regulation. Compound compatibility refers to that the formulation of Chinese medicinal prescriptions involves the complex synergy and interactions between sovereign, minister, assistant, and guide medicinal materials. Multiple effects mean that the prescriptions employ a variety of mechanisms to exert comprehensive pharmacological effects of nonlinear feedback. Moderate regulation reflects that the prescriptions can accurately regulate the multiple points of the disease biological network as a whole. To solve the mystery of Yiyin decoction theory, we should not only simply study the known active substances(components) and their independent target effects in the mixture, but also mine the "dark matter" and "dark effect" of Chinese medicinal prescriptions. That is, we should learn the neglected atypical pharmacological effects of Chinese medicinal prescriptions and the multi-point nesting mechanism that plays a precise regulatory function in the body. Yiyin decoction theory focuses on the overall pharmacological effect to reflect the comprehensive clinical value of Chinese medicinal prescriptions, which is of great significance for the development of a new model for the evaluation and application of new Chinese medicinal prescriptions in line with the theory of traditional Chinese medicine.
