Association between pancreatic cancer and diabetes
10.3969/j.issn.1001-5256.2022.12.039
- VernacularTitle:胰腺癌与糖尿病的关系
- Author:
Shengchen NAN
1
;
Qiao SHI
1
;
Chen CHEN
2
;
Weixing WANG
1
Author Information
1. Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
2. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Reviews
- Keywords:
Pancreatic Neoplasms;
Diabetes Mellitus;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(12):2882-2886
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is a type of highly malignant digestive system tumor, with a 5-year overall survival rate of < 10%. In recent years, a large number of studies have shown that there is a two-way relationship between pancreatic cancer and diabetes; diabetes is not only one of the high-risk factors for pancreatic cancer, but also a paraneoplastic phenomenon caused by pancreatic cancer. Hyperglycemia and hyperinsulinemia in patients with type 2 diabetes are risk factors for pancreatic cancer, and on the contrary, pancreatic cancer cells cause the dysfunction of pancreatic β cells through autocrine or paracrine pathways and thus lead to the onset of pancreatic diabetes. This article reviews the epidemiology and pathogenesis of pancreatic cancer and the two-way relationship between pancreatic cancer and diabetes, so as to provide a reference for clinical practice.
