Multi-scale Mechanisms of Maxing Shigantang in Treating Pneumonia Based on Transcriptomic Data
10.13422/j.cnki.syfjx.20221417
- VernacularTitle:基于转录组数据解析麻杏石甘汤治疗肺炎的多尺度作用机制
- Author:
Peng LI
1
;
Yuanyuan ZHANG
1
;
Haoran ZHANG
1
;
Lingmin ZHAN
1
;
Wuxia ZHANG
1
;
Chen BAI
2
;
Jianxin CHEN
2
Author Information
1. Shanxi Key Lab for Modernization of Traditional Chinese Veterinary Medicine， College of Basic Sciences， Shanxi Agricultural University， Jinzhong 030801， China
2. School of Traditional Chinese Medicine， Beijing University of Chinese Medicine， Beijing 100029， China
- Publication Type:Journal Article
- Keywords:
transcriptome;
network pharmacology;
Maxing Shigantang;
pneumonia;
immune response
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(1):82-90
- CountryChina
- Language:Chinese
-
Abstract:
ObjectivePneumonia is an infectious inflammation of the alveoli， distal airway， and interstitium caused by bacterial， viral， and other pathogens. Maxing Shigantang， originated from Treatise On Cold Damage Diseases， is a classic prescription for treating pneumonia， with significant clinical efficacy. However， its treatment mechanism is still elusive. MethodIn that paper， the transcriptome-based multi-scale network pharmacology was used to reveal the overall pharmacological mechanism of Maxing Shigantang in treating pneumonia from six scales of tissue， cell， pathological process， biological process， signaling pathway， and target. ResultAt the tissue level， Maxing Shigantang mainly acted on the focal tissue of pneumonia-lung and the main inflammatory immune tissues-blood and spleen. Analysis of cell， pathological process and biological process suggested that Maxing Shigantang could treat pneumonia by reversing inflammatory and immune functions and improving cardiopulmonary and vascular injury caused by pneumonia. Analysis of signaling pathway and target showed that Maxing Shigantang regulated inflammatory immune response pathways such as "coronavirus disease-COVID-19" and "Toll-like receptor signaling pathway"， and related targets such as "MAPKAPK3" and "NRG1". ConclusionThis paper， from molecular to tissue levels， indicated Maxing Shigantang treated pneumonia mainly by regulating inflammatory immune response and improving cardiopulmonary and vascular injury.
