Research progress in volatile oil microemulsion gel of traditional Chinese medicine
- VernacularTitle:中药挥发油微乳凝胶剂的研究进展
- Author:
Hui LIU
1
;
Jia YIN
2
;
Jingyi WANG
1
;
Chaoyue LIU
3
;
Xin WANG
4
;
Jingwei LI
5
;
Chunsheng FU
5
Author Information
1. School of Pharmacy，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. Dept. of Thyroid and Breast Surgery，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250011，China
3. School of Anesthesiology，Weifang Medical University，Shandong Weifang 261053，China
4. Dept. of Pharmacy，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250011，China
5. Dept. of Science and Technology，the Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250011，China
- Publication Type:Journal Article
- Keywords:
volatile oil of traditional Chinese medicine
- From:
China Pharmacy
2022;33(22):2812-2816
- CountryChina
- Language:Chinese
-
Abstract:
Volatile oil microemulsion gel of traditional Chinese medicine has the dual characteristics of microemulsion and gel， which can improve the solubility and stability of drugs， promote drug absorption and achieve long-term sustained release effect. In recent years， it has been widely used in clinical diseases such as internal medicine， gynecology and pediatrics. In this paper， the characteristics， prescription design， molding process and quality evaluation of volatile oil microemulsion gel of traditional Chinese medicine were reviewed by searching relevant literature. The results showed that the volatile oil microemulsion gel had the characteristics of improving the stability of the drug， increasing the transdermal penetration of the drug， strong adhesion， easy to wash， convenient preparation， etc. The prescription design consists of oil phase， surfactant， cosurfactant and gel matrix. The molding process includes the molding process of microemulsion and the molding process of gel， and the formation of microemulsion mainly uses the pseudo-ternary phase diagram method. The quality evaluation can be divided into 2 parts： volatile oil of traditional Chinese medicine and microemulsion gel. The quality evaluation of volatile oil can be studied qualitatively and quantitatively. Microemulsion gel should meet the relevant requirements and be tested for in vitro release and transdermal absorption.
