Relationship between low-level viraemia and virus inhibition failure and its influencing factors in HIV-infected patients in Hubei Province
10.3969/j.issn.1006-2483.2022.06.021
- VernacularTitle:湖北省HIV感染者低病毒血症和病毒抑制失败的关联及影响因素
- Author:
Meng GUO
1
;
Cong LIU
1
;
Fang-hua MEI
1
;
Wu ZHENG
1
;
Kun CAI
1
Author Information
1. Hubei Provincial Center for Disease Control and Prevention , Wuhan , Hubei 430079 , China
- Publication Type:Journal Article
- Keywords:
Plasma viral load;
Low level viremia;
Continuous virus inhibition;
Virological suppression failure
- From:
Journal of Public Health and Preventive Medicine
2022;33(6):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of low-level viraemia (LLV) on virus inhibition failure (VF) in HIV infected patients treated with first-line antiretroviral therapy (ART) in Hubei Province, and to explore the factors affecting LLV. Methods People infected with HIV who were newly diagnosed in Hubei Province from 2015-2016, had first-line ART for≥6 months, and achieved continuous virological suppression (two consecutive plasma viral load [VL] <50 copies/mL) were included in this study. Data including follow-up time, VL testing time and results, demographic characteristics, route of infection, baseline CD4+T lymphocyte count, WHO clinical stage, and treatment plan were collected. The incidence of LLV and VF was statistically analyzed, and the effect of different levels of LLV on VF was compared. Logistic regression analysis was used to explore the influencing factors of the occurrence of LLV in HIV infected patients. Results A total of 881 HIV-infected patients were included in this study, and a total of 3428 person-years were followed up, with an average follow-up time of (3.40±1.20) person-years. 304 patients (34.51%) had at least one LLV after ART. K-M survival curve analysis showed that the higher the LLV level, the higher the risk of VF (P<0.01). Logistics regression analysis showed that the influencing factors for LLV in HIV-infected patients with first-line ART were age ≥51 years old (OR=1.755), heterosexual transmission (OR=0.812), and baseline CD4+T lymphocyte count of 50-200 /mm3 (OR=1.425). Conclusion For HIV-infected patients with first-line ART in Hubei Province, the occurrence of LLV will increase the risk of subsequent VF and increase with the increase of LLV level. It is necessary to increase the monitoring frequency of VL in treated HIV patients and to intervene in time.
