Hippo pathway and its research progress in ophthalmology
10.3980/j.issn.1672-5123.2022.12.07
- VernacularTitle:Hippo通路及其在眼科领域的研究进展
- Author:
Qi-Hang SUN
1
;
Xu-Hua TAN
1
;
Li-Xia LUO
1
Author Information
1. Zhongshan Ophthalmic Center, Sun Yat-sen University;State Key Laboratory of Ophthalmology;Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
Hippo pathway;
development;
regeneration;
lens;
retina
- From:
International Eye Science
2022;22(12):1971-1976
- CountryChina
- Language:Chinese
-
Abstract:
The Hippo pathway, regulated by multiple intracellular and extracellular signals, is an evolutionarily conserved signaling pathway. Through YAP/TAZ,the effector molecule, Hippo pathway participates in a variety of important physiological activities such as regulating the proliferation, differentiation, migration and regeneration of cells. Extensive studies have revealed that the Hippo pathway involves in tissue development, organ regeneration and tumorigenesis. Recent studies have shown that the Hippo pathway is closely related to the development and regeneration of ocular tissues and development of ocular diseases. Elucidating the role of Hippo pathway in ocular tissues will help to reveal the mechanism of occurrence and development of ophthalmic diseases, and it has far-reaching significance for improving the basic research and guiding the clinical work of ophthalmology. In this manuscript, the components and functions of the Hippo pathway and the recent research progress of Hippo pathway in ocular tissues such as cornea, trabecular meshwork, lens, retina and uvea were reviewed.
