Xin'an Special Preparation Gandouling Tablets for Treatment of Hepatolenticular Degeneration： A Review
10.13422/j.cnki.syfjx.20222396
- VernacularTitle:新安特色制剂肝豆灵片治疗肝豆状核变性的研究进展
- Author:
Yuting ZHANG
1
;
Lihua LI
1
;
Hao CHEN
1
Author Information
1. Chinese Medicine Preparations Laboratory （Level 3） of National Administration of Traditional Chinese Medicine，First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China
- Publication Type:Journal Article
- Keywords:
hepatolenticular degeneration;
Xin'an special preparation;
Gandouling tablets;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(23):97-102
- CountryChina
- Language:Chinese
-
Abstract:
The present study reviewed the relevant research on Gandouling tablets，a Xin'an special preparation for the treatment of hepatolenticular degeneration ［also known as Wilson's disease （WD）］ to provide a basis for the further development and research on Gandouling tablets. The research articles on Gandouling tablets in China and abroad were retrieved from China national knowledge infrastructure（CNKI）， and the clinical application and action mechanism of Gandouling tablets were collected. The results indicated that Gandouling tablets could improve liver function，cellular immune function，cognitive and memory impairment，and depression in patients with WD， effectively reduce Hamilton e-24 （HDRS-24） score，and promote the recovery of neurological function and renal function in patients with WD. The efficacy of Gandouling tablets in improving depression symptoms may be achieved by increasing serum levels of 5-hydroxytryptamine （5-HT），interleukin-10 （IL-10），macrophage migration inhibitory factor （MIF），etc. The pathogenesis of WD complicated with depression was related to the metabolism of monoamine neurotransmitters，the regulation of neural plasticity， and immune inflammatory response. Gandouling tablets have the effects of clearing heat，removing toxins， resolving blood stasis，softening hardness， promoting bile secretion， and expelling copper， and can effectively improve the neurological function， liver and kidney function， cognitive and memory impairment and other symptoms of patients with hepatolenticular degeneration.
