Safety and Comfort Analysis of Distal Transradial Access for Hepatic Artery Infusion Chemotherapy in the Treatment of Liver Cancer
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.20220506.001
- VernacularTitle:经远桡动脉入路HAIC治疗肝肿瘤的安全性和舒适性研究
- Author:
Bin CHEN
1
;
Hai-tao DAI
1
;
Run LIN
1
;
Chun-yong WEN
1
;
Gui-yuan ZHANG
1
;
Xian-hong XIANG
1
;
Jian-yong YANG
1
;
Yong-hui HUANG
1
Author Information
1. Department of Interventional Radiology， The First Affiliated Hospital， Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
distal transradial access;
transfemoral access;
hepatic artery infusion chemotherapy;
liver cancer;
quality of life
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2022;43(4):639-644
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the safety and comfort of hepatic artery infusion chemotherapy （HAIC） via distal transradial access （dTRA） in patients with liver cancer. MethodsPatients with advanced liver cancer who received HAIC via dTRA or transfemoral access （TFA） at the Department of Interventional Radiology， the First Affiliated Hospital of Sun Yat-sen University， were enrolled. The patients underwent dTRA or TFA for onetime and crossed-over subsequently. The patients received HAIC using FOLFOX4 regimen. Postcatheterization questionaire was used to compare the effects of the two vessel accesses on patients’ quality of life. Procedure-related adverse events were also recorded. ResultsAmong the 18 cases enrolled for HAIC， 9 underwent crossover from dTRA to TFA and the the remaining 9 from TFA to dTRA. During HAIC via dTRA， we only found grade 1 or grade 2 procedure-related adverse events such as 2 access site hematoma， 3 persistent pain at access site and 1 left palm numbness. No grade 3 or grade 4 procedure-related adverse event was found. Post dTRA ultrasound revealed no proximal radial artery occlusion. Significant difference in catheterization time between dTRA and TFA accesses was found （4 min vs. 3 min， P < 0.05）. All comfort scores were higher with dTRA as compared to TFA and patients preferred dTRA （7.89 vs. 2.72， P < 0.001）. The compression time for dTRA access was significantly shorter than TFA access （2 h vs. 7 h， P < 0.05）. ConclusionsdTRA approach is safe and tolerable， which is beneficial to improve the quality of life and comfort of patients with liver cancer when undergoing HAIC.
