Research progress on the anti-dementia effect of Dipsaci Radix and its active compounds
10.16438/j.0513-4870.2022-0729
- VernacularTitle:续断及其有效成分的抗痴呆作用及研究进展
- Author:
Jin-shuai CUI
1
;
Yan LIU
1
;
Zi-ying WANG
1
;
Gang CHENG
2
Author Information
1. Interdisciplinary Institute of Individualized Prevention and Treatment of Encephalopathy, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
2. Interdisciplinary Institute of Individualized Prevention and Treatment of Encephalopathy, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China; Key Laboratory of Endemic and Minority Diseases of Ministry of Education, Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
Dipsaci Radix;
ementia;
Alzheimer's disease;
cerebral stroke;
vascular dementia
- From:
Acta Pharmaceutica Sinica
2022;57(10):3057-3066
- CountryChina
- Language:Chinese
-
Abstract:
Dementia is a series of diseases with severe cognitive decline caused by brain diseases, that closely related to kidney deficiency in traditional Chinese medicine, including Alzheimer's disease (AD), dementia caused by cerebral stroke, vascular dementia (VAD) and so on. Dipsaci Radix is the dried root of Dipsacus asper Wall. ex Henry and its curative effects mainly focus on nourishing the liver and kidney, strengthening muscles and bones, as well as dredging blood vessels. The main chemical components of Dipsaci Radix are triterpenoid saponins and iridoid glycosides. In recent years, studies have found that Dipsaci Radix and its active compounds could ameliorate dementia symptoms via multiple targets and molecular mechanisms. In this review, we summarize the recent research progress of Dipsaci Radix in dementia prevention, which will provide reference for further exploration of its mechanism and application in the prevention and treatment of dementia.
