A new patchoulane-type sesquiterpenoid from patchouli oil and its anti-inflammatory activity
10.16438/j.0513-4870.2022-0514
- VernacularTitle:广藿香油中1个新的广藿香烷型倍半萜及其抗炎活性
- Author:
Tian-hao ZHANG
1
;
Cheng PENG
1
;
Jing ZUO
1
;
Qi ZHENG
1
;
Chun-wang MENG
1
;
Li GUO
1
;
Qin-mei ZHOU
2
;
Liang XIONG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Innovation Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
patchouli oil;
patchoulane type;
sesquiterpenoid;
anti-inflammation;
RAW264.7 cell
- From:
Acta Pharmaceutica Sinica
2022;57(10):3163-3167
- CountryChina
- Language:Chinese
-
Abstract:
A new [7,10∶1,5]-patchoulane-type sesquiterpenoid was isolated and purified by silica gel column chromatography, medium pressure liquid chromatography, and semi-preparative high performance liquid chromatography. Based on IR, HR-ESI-MS, NMR, and X-single crystal diffraction data analyses, compound 1 was determined to be (-)-(3S,4R,5R,7R,10R)-[7,10∶1,5]patchoul-1(2)-en-3,4-diol. It showed an inhibitory effect on LPS-induced NO production in RAW264.7 cells.
