Research progress on hydrogels as osteoimmunomodulatory biomaterials
10.12016/j.issn.2096-1456.2023.01.013
- Author:
HE Lulu
1
;
WANG Hang
1
;
XIE Huiqi
2
Author Information
1. Department of Prosthodontics, West China Hospital of Stomatology Sichuan University &National Clinical Research Center for Oral Diseases &State Key Laboratory of Oral Diseases
2. West China Hospital Sichuan University &State Key Laboratory of Biotherapy
- Publication Type:Review
- Keywords:
hydrogels;
physicochemical property;
osteoimmunology;
bone regeneration;
immune response;
foreign body reaction;
macrophages;
crosslinking
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(1):68-72
- CountryChina
- Language:Chinese
-
Abstract:
With the advances in understanding the relationships among biomaterials, the immune system and the skeletal system, the host responses elicited by implanted biomaterials can be balanced by properly designing material characteristics from the perspective of osteoimmunology. The immunoregulatory properties of bone tissue engineering scaffolds provide advantages for inducing macrophages from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype and promoting osseointegration. Hydrogels are increasingly a focus in bone tissue engineering, and the immune response can be affected by different compositions of hydrogels, such as the sources, concentration, molecular weight, coupling with fibronectin, and the addition of cross-linking agents. Different physicochemical properties of modified hydrogels can trigger different host immune responses, modified by using soft photolithography to fabricate micropatterned hydrogels, adding enzyme-sensitive sequences, ester bonds and dynamic covalent chemistry to prevent rapid or slow degradation of the hydrogels, and adding porogens and 3D printing to modify the hydrogels with macroporous interconnective pore structures, soft and injectable hydrogels, etc. These optimized hydrogels can reduce proinflammatory factors, promote M2 macrophage polarization, and minimize foreign body reactions to evoke bone regeneration. However, the mechanism underlying the bone immune response is still poorly understood, and further study of the effects of hydrogels with different physicochemical properties on immune regulation is needed.
- Full text:水凝胶作为骨免疫调节性生物材料的研究进展.pdf
