Development and progress of liver xenotransplantation: A potential breakthrough for current shortage of donor liver
10.3969/j.issn.1001-5256.2022.10.001
- VernacularTitle:突破供肝短缺难题：异种肝移植的发展与创新
- Author:
Xiao LI
1
;
Kefeng DOU
1
Author Information
1. Department of Hepato-Biliary Surgery and Army Institute of Organ Transplantation, Xijing Hospital, Air Force Military Medical University, Xi'an 710032, China
- Publication Type:Editorial
- Keywords:
Liver Transplantation;
Transplantation, Heterologous;
Animals, Genetically Modified
- From:
Journal of Clinical Hepatology
2022;38(10):2201-2205
- CountryChina
- Language:Chinese
-
Abstract:
The donor liver shortage is the bottles-neck limitation for clinical liver transplantation to save patients' life. Liver transplantation is a treatment option for end-stage liver diseases, like Cirrhosis and hepatocellular carcinoma, and acute liver failure; however, due to availability of donor liver, lots of patients never received such treatment option and passed way. Most recently, non-human primates after a liver transplantation with GTKO pigs survived for nearly 1 month indicates a promise of clinical use of liver xenotransplantation and could offer "a bridge transplantation" for fulminant liver failure patients. This review discussed and summarized the advancement and progress in the field, i.e., history of liver xenotransplantation research, model animals, clinical selection criteria, and future research directions and clinical trials.
