Preemptive Analgesic Effects of Dezocine on Emergence Delirium in Children Undergoing Concealed Penis Correction： a Clinical Observation
- VernacularTitle:地佐辛超前镇痛对隐匿性阴茎矫治术患儿苏醒期谵妄的临床观察
- Author:
Ying-ying SUN
1
;
Yu-zhu CAI
1
;
Ling-li ZHANG
1
;
Wei-fan LU
1
;
Man WANG
1
Author Information
1. Department of anesthesia， Anhui provincial children′s hospital， Hefei 230051，China
- Publication Type:Journal Article
- Keywords:
dezocine;
preemptive analgesia;
pediatric;
emergence delirium （ED）
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(1):102-108
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the preemptive analgesic effects of dezocine on emergence delirium （ED） in children undergoing concealed penis correction. MethodsSixty-two 6~10 years old boys scheduled for concealed penis correction under general anesthesia from July 2020 to October 2020 were randomly divided into normal saline control group （Group C， n=32） and dezocine group （Group D， n=30）. Five minutes before the anesthetic induction， Group C was treated with 10 mL of 0.9% normal saline and Group D with same amount of dezocine 0.1 mg/kg （diluted to 10 mL by 0.9% saline）. Pediatric Anesthesia Emergence Delirium scale （PAED） scores and Face， Legs， Activity， Cry， Consolability scale （FLACC） scores of the two groups were recorded and compared at the time points of entering postanesthesia care unit （PACU） （T1）， 10 min after entering PACU （T2）， leaving PACU （T3）， 1 h （T4） and 6 h （T5） after the surgery. The postoperative incidence of ED and urinary catheter-related bladder discomfort （CRBD） were compared between the two groups. Newly occurred maladaptive behaviors within 48 h after surgery were documented by parents in a questionnaire and compared between the two groups. We also compared the levels of cortisol， epinephrine and blood glucose at 30 min before induction （T0）， T1， T4 and T5 between the two groups. ResultsPAED scores and FLACC scores at T1 to T5 in Group D were significantly lower than those in Group C （both P<0.001）. Group D had lower incidence of ED （16.67% vs. 40.63%，P=0.039）， CRBD （6.67% vs. 28.13%，P=0.044） and newly occurred maladaptive behaviors within 48 h after surgery （13.33% vs. 37.50%， P=0.042）. The levels of cortisol， epinephrine and glucose were significantly lower in Group D at T1， T4， T5 （P<0.001， P=0.009 and P=0.012， respectively） than those in Group C. ConclusionsPreemptive analgesia by using dezocine can significantly reduce the the incidence of ED and newly occurred maladaptive behaviors in children undergoing concealed penis correction， which could be explained by the fact that dezocine can reduce the postoperative pain stress and the incidence of CRBD.
