Change of Plasma Level of Soluble NRP-1 and SOD in Hypertensive Patients and Hypertensive Diabetic Patients
- VernacularTitle:高血压及高血压合并糖尿病的患者血浆可溶性NRP-1与SOD浓度的变化
- Author:
Shu-jie YU
1
;
Ding-hui LIU
1
;
Zhi-ming SONG
2
;
Xiao-xian QIAN
1
Author Information
1. Department of Cardiology， The Third Affiliated Hospital， Guangzhou 510630， China
2. Department of Cardiology， The First Affiliated Hospital， Henan University， Kaifeng 475001， China
- Publication Type:Journal Article
- Keywords:
neuropilin-1;
superoxide dismutase;
hypertension;
diabetes mellitus;
angiogenesis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(1):81-86
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the changes of plasma levels of soluble neuropilin-1 and superoxide dismutase （SOD） in hypertensive patients and hypertensive diabetic patients. MethodsIn this cross-sectional study， eighty-eight cases were enrolled， which were divided into hypertensive group （n=31）， hypertensive diabetic group （n=31） and control group （n=26）. The levels of neuropilin-1 and SODwere measured by ELISA. Meanwhile， the levels of serum glucose， glycosylated hemoglobin A1C （GHbA1c） and lipid profile were detected. ResultsThe levels of total cholesterol （TC） and body mass index （BMI） were significantly higher in the hypertensive group than those in control group （P<0.05）. The levels of TC， low density lipoprotein cholesterol （LDL-C）， triglyceride （TG）， BMI， waist circumference were significantly higher in the hypertensive diabetic group than those in control group （P<0.05）. The mean plasma levels of neuropilin-1 and SOD in both hypertensive diabetic group and hypertensive group were significantly decreased compared with that in the normal group［NRP-1（ng/mL）：6.8（6.0~8.3），5.2（4.0~6.8）vs 8.9（7.7~10.0）；SOD（U/mL）：157.1±18.6，145.1±31.4 vs 168.4±23.1，P<0.05］While the mean plasma levels of neuropilin-1 and SOD in hypertensive diabetic group were significantly decreased compared withthat of the hypertensive group［NRP-1（ng/mL）：5.2（4.0~6.8）vs 6.8（6.0~8.3）；SOD（U/mL）： 145.1±31.4 vs 157.1±18.6，P<0.05］. The linear correlation analysis of three groups of study population found that neuropilin-1 and SOD showed significant positive correlation （r=0.539，0.660，0.895， P<0.05）. ConclusionsThe plasma concentration of neuropilin-1 is decreased in both hypertensive and hypertensive diabetic patients， and more decreased in hypertensive diabetic patients. Decreased neuropilin-1 concentration may be associated with the reduction of SOD activity.
