Changes of serum lipoxin A4, vitamin D and IL-18 and their correlation with lung function in patients with bronchial asthma
10.3969/j.issn.1006-2483.2022.05.023
- VernacularTitle:支气管哮喘患者血清脂氧素A4维生素D和IL-18水平变化及其与肺功能的相关性
- Author:
Dan-fen YANG
1
;
Peng-fei JIANG
1
;
Xiao-qi HUANG
1
;
Yuan-yuan XIE
1
Author Information
1. Department of Geriatrics , Affiliated Hospital of Yan'an University , Yan'an , Shaanxi 716000 , China
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Lung function;
Lipoxin A4;
Vitamin D
- From:
Journal of Public Health and Preventive Medicine
2022;33(5):100-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum lipoxin A4(LXA4), vitamin D and IL-18 levels and their correlation with lung function in patients with bronchial asthma, and to provide theoretical basis for clinical evaluation of bronchial asthma lung function. Methods A total of 284 patients with bronchial asthma admitted to our hospital from March 2018 to March 2020 were selected from the observation group, and 284 healthy normal people who received physical examination in our hospital during the same period were selected from the control group. The FEV1% and serum levels of LXA4, 25 hydroxyvitamin D3[25(OH)D3] and IL-18 in both groups were determined. Pearson correlation analysis was conducted between serum LXA4, vitamin D and IL-18 levels and lung function in patients with bronchial asthma. Results The FEV1% value in observation group was significantly lower than that in control group (t=56.059，P<0.05). The FEV1% value in acute attack stage was significantly lower than that in chronic duration and clinical remission stage (t1=8.605，t1=23.464，P<0.05). The serum LXA4 and 25(OH)D3 levels in observation group were significantly lower than those in control group, and the serum IL-18 level was significantly higher than that in control group (P<0.05). The levels of serum LXA4 and 25(OH)D3 in acute attack stage were significantly lower than those in chronic duration and clinical remission stage, and the levels of serum IL-18 were significantly higher than those in chronic duration and clinical remission stage (P<0.05). The levels of serum LXA4 and 25(OH)D3 in chronic asthma were significantly lower than those in clinical remission, and the levels of serum IL-18 were significantly higher than those in clinical remission (P<0.05).Pearson correlation analysis showed that 25(OH)D3 was positively correlated with FEV1% value (r=0.519, P<0.05). LXA4 and IL-18 was positively related with FEV1% values (r1=-0.492, r1=-0.615, P<0.05) . Conclusion LXA4, vitamin D and IL-18 can be used as markers to assess lung function in bronchial asthma.
