Diagnostic value of CD64 index, human neutrophil apolipoprotein and PCT in the diagnosis of bacterial infection in patients with AECOPD
10.3969/j.issn.1006-2483.2022.05.018
- VernacularTitle:CD64指数、人中性粒细胞载脂蛋白及PCT对AECOPD患者的诊断价值
- Author:
Hong-mei CHEN
1
;
Yan-yan YU
1
;
Zhe FANG
1
;
Tian YUAN
1
;
Yuan JIANG
1
Author Information
1. Department of Internal Medicine , Hunan Provincial Tuberculosis Control Hospital (Hunan Provincial Chest Hospital) , Changsha , Hunan 410006 , China
- Publication Type:Journal Article
- Keywords:
CD64 index;
Human neutrophil apolipoprotein;
Procalcitonin;
Acute exacerbation of chronic obstructive pulmonary disease;
Bacterial infectionn;
Diagnostic value
- From:
Journal of Public Health and Preventive Medicine
2022;33(5):77-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of CD64 index, human neutrophil apolipoprotein and procalcitonin (PCT) in the diagnosis of bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 97 patients with AECOPD who were treated in our hospital from May 2019 to March 2021 were selected as the observation group, and 97 healthy people who received physical examination in our hospital during the same period were selected as the control group by 1:1 pairing of gender and age (±5 years old). Five ml of fasting peripheral venous blood was taken from the subjects to detect CD64 index, human neutrophil apolipoprotein and PCT. The levels of the above-mentioned laboratory indicators between the observation group and the control group were compared. According to the presence or absence of respiratory tract infection, the observation group was divided into a bacterial infection group and a non-bacterial infection group. The above indicators of the two groups were compared, and the ROC analysis method was used to determine the diagnostic value of individual detection alone and combined examination for bacterial infection in AECOPD patients. Results The levels of CD64 index, human neutrophil apolipoprotein and PCT in the observation group were higher than those in the control group (P<0.05). The levels of CD64 index, human neutrophil apolipoprotein and PCT in the bacterial infection group were higher than those in the non-bacterial infection group (P<0.05). ROC analysis showed that the cut-off values of CD64 index, human neutrophil apolipoprotein and PCT in the diagnosis of bacterial infection in AECOPD patients were 12.95%, 82.04μ g/L, and 1.65 ng/L, respectively. The values of the area under the curve (AUC) were 0.883, 0.806 and 0.759, respectively. The AUC of the combined detection of CD64index, human neutrophil apolipoprotein and PCT in AECOPD patients was 0.924, which was higher than the cut-off value of each index alone (P<0.05). Conclusion There are significant differences in CD64 index, human neutrophil apolipoprotein and PCT among healthy people, AECOPD non-bacterial infected patients and AECOPD bacterial infected patients. All three indexes can be used to diagnose bacterial infection in AECOPD patients, and combined detection of the three indexes can improve the diagnostic efficiency.
