Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A
- VernacularTitle:环孢素A个体化用药临床预后的实验室检查指标研究进展
- Author:
Jinwei HU
1
;
Huaijun ZHU
2
;
Qianying LAO
1
;
Danying LI
2
Author Information
1. Dept. of Pharmacy，Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School，Nanjing 210008，China;Drum Tower Clinical College of Integrated Chinese and Western Medicine，Nanjing University of Chinese Medicine，Nanjing 210008，China
2. Dept. of Pharmacy，Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School，Nanjing 210008，China
- Publication Type:Journal Article
- Keywords:
cyclosporine A;
therapeutic drug monitoring;
clinical effi cacy;
safety;
laboratory examination index
- From:
China Pharmacy
2022;33(18):2285-2289
- CountryChina
- Language:Chinese
-
Abstract:
Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ，the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects ：the cyclosporine A concentration of peripheral blood mononuclear cells ，calcineurin activity ，T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ，which can make up for the insufficiency of blood drug concentration monitoring ，and the clinical practicability needs to be further improved .
