Progress on contact lens for extended ophthalmic drug delivery
10.3980/j.issn.1672-5123.2022.10.10
- VernacularTitle:基于角膜接触镜的眼部长效给药技术研究进展
- Author:
Zhao WANG
1
;
Qing LIN
1
;
Xiao-Juan ZHANG
1
;
Xiao-Mei WANG
1
;
Ling-Yun HAO
1
Author Information
1. Jinling Institute of Technology, Nanjing 211169, Jiangsu Province, China; Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing 211169, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
contact lens;
drug delivery;
sustained drug release;
vitamin E;
molecular imprinting technology;
nanoparticles
- From:
International Eye Science
2022;22(10):1647-1651
- CountryChina
- Language:Chinese
-
Abstract:
Conventional eye treatment formulation such as eye drops has shortcomings including low drug utilization and poor patient compliance. The contact lens(CL), well-known as visual correction lens, is considered to be a more promising ophthalmic drug delivery vehicle owing to its good biocompatibility, long-term wearing comfort, prolonged drug residence time and improved bioavailability. In order to improve the drug loading efficiency and prolong the release time, researchers have developed a variety of strategies to modify traditional CL, including the introduction of vitamin E molecular barrier, application of molecular imprinting technology of CL, increasing interactions between the drug and polymer matrix by introducing special genes, and incorporation of nanocarriers or drug-loaded polymer films. In this paper, the preparation methods and pros and cons of drug-loaded CL are reviewed. At last, the existing problems and future developments of CL as ophthalmic drug delivery carrier are briefly discussed.
