Pharmacological Mechanism of Curcumae Radix in Treatment of Post-stroke Depression： A Review
10.13422/j.cnki.syfjx.20220740
- VernacularTitle:郁金治疗卒中后抑郁的药理机制研究进展
- Author:
Jian-fu MA
1
;
Dou WANG
1
;
Tao LI
1
;
Zhuo CHEN
1
;
Ming-dong FAN
1
;
Yan LI
1
;
Yong-mei YAN
1
Author Information
1. The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine， Affiliated Hospital， Xianyang 712000 ，China
- Publication Type:Journal Article
- Keywords:
Curcumae Radix;
post-stroke depression;
curcumin;
pharmacological mechanism;
nervous system
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(7):276-282
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression， a common mental complication after stroke， seriously affects the quality of life and even endangers the life safety of patients. It is difficult to be cured due to the complex and diverse pathogenesis. At present， the widely accepted pathogenesis mechanisms include inflammatory mechanism， neurotransmitter mechanism， and endocrine mechanism. According to the theory of Chinese medicine， Qi stagnation， blood stasis， and phlegm turbidity lead to the occurrence of mental diseases after stroke. Curcumae Radix， as a commonly used Chinese herbal medicine， can activate blood circulation for relieving pain， regulate Qi， and relieve depression. The summary of the medication rules of DENG Tie-tao， ZHANG Xue-wen and other Chinese medical physicians showcases that Curcumae Radix is frequently used in the clinical treatment of depression， stroke， and post-stroke depression. Modern pharmacological studies have demonstrated that Curcumae Radix contains β-sitosterol， curdione， curcumin and other medicinal ingredients. This study reviewed the pharmacological effects of effective components in Curcumae Radix and the pharmacological mechanism in the treatment of post-stroke depression and summarized the processing methods of Curcumae Radix， aiming to clarify the important role and determine the optimal processing method of Curcumae Radix in the treatment of post-stroke depression. The results indicate that Curcumae Radix has the effects of regulating neurotransmitters， inhibiting neuroinflammation， protecting neurons， regulating neuroendocrine and antithrombosis， which can prevent and treat post-stroke depression through multiple components， targets， and pathways. The wine-processed Curcuma longa has the best effect.
