Combined Therapy of Lung and Intestine in Treatment of Lung Diseases： A Review
10.13422/j.cnki.syfjx.20220708
- VernacularTitle:肺肠合治法治疗肺系疾病的研究进展
- Author:
Sheng-chuan BAO
1
;
Shu-guang YAN
1
;
Ting CHEN
1
;
Juan CHEN
1
;
Jing-tao LI
2
;
Yi HUI
1
Author Information
1. College of Basic Medicine，Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. Affiliated Hospital to Shaanxi University of Chinese Medicine，Xianyang 712000，China
- Publication Type:Journal Article
- Keywords:
combined therapy of lung and intestine;
mucous membrane;
microorganism;
lung-intestine axis;
immunity
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(8):116-122
- CountryChina
- Language:Chinese
-
Abstract:
The theoretical origin of the combined therapy of lung and intestine can be traced back to the Inner Canon of Huangdi （《黄帝内经》）， which explains the physiological and pathological interaction between the lung and the large intestine. In recent years， researchers have investigated the scientific essence of the "lung-intestine axis" theory from many aspects， which enriches the relevant theoretical basis， and applied it to the treatment of COVID-19， acute lung injury， and other lung diseases. The close relation between lung and intestine in many aspects embodies the holistic conception of traditional Chinese medicine and explains the holistic theory of interrelation between organs， which correlate to each other physiologically and pathologically. Intestinal microecological disorders can affect lung immune function and cause respiratory diseases， and respiratory diseases are usually accompanied by gastrointestinal symptoms. Lung diseases can be prevented and treated by regulating intestinal flora. According to histoembryology， the epithelial tissue of the lung and intestine comes from primitive foregut. In immunology， both lung and intestine contain mucosa-associated lymphoid tissue， and the pathological changes of the respiratory tract are also closely related to intestinal microorganisms. The tissue origin of lung and large intestine， the correlation of mucosal immunity， and the synchronization of ecological changes provide a scientific basis for the combined therapy of lung and intestine. Therefore， this paper summarizes the theoretical origin， modern research mechanism， and clinical application of combined therapy of lung and intestine， in order to provide a new direction for its application in clinical and scientific research.
