Anti-Newcastle Disease Virus activity of 3β and 3α Friedelanol Triterpenoids from the leaves of Synadenium glaucescens Pax
https://doi.org/10.47665/tb.39.2.016
- Author:
Credo, D.
1
;
Mabiki, F.P.
2
;
Machumi, F.
3
;
Chacha, M.
4
;
Cornett, C.
5
;
Styrishave, B.
5
Author Information
1. Department of Chemistry and Physics, College of Natural and Applied Science-Sokoine University of Agriculture, P.O. BOX 3038 Morogoro, Tanzania&Department of Natural Products Development and Formulation, Institute of Traditional Medicine-Muhimbili University of Health and Allied Science, P.O. BOX 65001 Dar es Salaam, Tanzania&Departmentl of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Kobenhavn, Denmark
2. Department of Chemistry and Physics, College of Natural and Applied Science-Sokoine University of Agriculture, P.O. BOX 3038 Morogoro, Tanzania&
3. Department of Natural Products Development and Formulation, Institute of Traditional Medicine-Muhimbili University of Health and Allied Science, P.O. BOX 65001 Dar es Salaam, Tanzania&
4. Department of Sustainable Agriculture and Biodiversity Ecosystem Management, School of Life Sciences and Bioengineering, Nelson Mandela African Institute of Science and Technology, P.O. BOX 447 Arusha, Tanzania
5. Departmentl of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Kobenhavn, Denmark
- Publication Type:Journal Article
- Keywords:
Antiviral activity;
bioactive compounds;
friedelane triterpenoids;
in ovo assay;
poultry viral diseases.
- From:Tropical Biomedicine
2022;39(No.2):257-264
- CountryMalaysia
- Language:English
-
Abstract:
Newcastle Disease (ND) is a highly pathogenic disease of avian species which is caused by Newcastle
Disease Virus (NDV). It is one of the major causes of mortality and morbidity to poultry industry in the
third world countries. Currently, there is no treatment measures against ND; the only existing measure
is vaccination, though it is incapable to offer 100% immunity. In Tanzania, the leaves of Synadenium
glaucescens Pax. are traditionally used for treatment of various ailments including ND. Previously, its
leaves extract has been scientifically confirmed to exhibit anti-NDV activity though bioactive compound(s)
responsible for this activity is/are unknown. Therefore, this study was aimed to evaluate anti-NDV
activity of 3β-Friedelanol (1) and 3α-friedelanol (2) isolated from its leaves extract. Isolation of these
compounds was achieved by column chromatography method whereas, their chemical structures were
determined by Nuclear Magnetic Resonance (NMR) data and by comparing with the available literature
NMR data. Anti-NDV activity study was done in embryonated chicken eggs (ECEs). Treatment of NDV
inoculated ECEs with 3β-Friedelanol (1) reduced the viral load to zero and maintained the survival of
embryos, this was revealed by continuous organs formation and increase in embryo weights with no
significant different (p > 0.05) from un-inoculated ECE. These effects suggest that, 3β-Friedelanol (1)
possesses anti-NDV activity. Therefore, existence of 3β-Friedelanol (1) in the leaves of S. glaucescens
may justify its earlier described anti-NDV activity and traditional use in the treatment of ND. Hence, its
leaves extract may be considered for development of anti-NDV herbal formulation while 3β-Friedelanol
could either serve as a drug or lead compound for synthesis of anti-NDV drugs.
- Full text:8.2022my1341.pdf
