Ascyrones A-E, type B bicyclic ployprenylated acylphloroglucinol derivatives from Hypericum ascyron.
10.1016/S1875-5364(22)60167-5
- Author:
Xin DENG
1
;
Jing XIA
1
;
Meng-Yu QIAN
1
;
Xiu-Rong WANG
1
;
Bo HU
1
;
Xue-Song LIU
2
,
3
;
Lin WU
4
Author Information
1. School of Pharmacy, Anhui Medical University; Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China.
2. School of Pharmacy, Anhui Medical University; Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China. Electronic address: chemxsliu@
3. com.
4. School of Pharmacy, Anhui Medical University; Inflammation and Immune Mediated Disease Laboratory of Anhui Province, Hefei 230032, China. Electronic address: wulin@ahmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Acylphloroglucinol;
Anti-inflammatory activity;
Hypericum ascyron;
Neuroprotective activity
- MeSH:
Animals;
Anti-Inflammatory Agents/pharmacology*;
Hypericum/chemistry*;
Molecular Structure;
PC12 Cells;
Phloroglucinol/pharmacology*;
Rats
- From:
Chinese Journal of Natural Medicines (English Ed.)
2022;20(6):473-480
- CountryChina
- Language:English
-
Abstract:
Five new polycyclic polyprenylated acylphloroglucinols (1-5), ascyrones A-E, and four known compounds (6-9) were isolated from the aerial parts of Hypericum ascyron. All of the isolates containing a bicyclo[3.3.1]nonane-2,4,9-trione core and a benzoyl group, belonged to type B bicyclic polyprenylated acylphloroglucinols (BPAPs). Their structures and absolute configurations were established based on spectroscopic analyses and calculated electronic circular dichroism (ECD) data. The anti-inflammatory, neuroprotective and cytotoxicity activities of compounds 1-4 and 6-9 were evaluated. Compound 6 exhibited obvious anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 cells. Compounds 1 and 9 exhibited slight cytotoxicity against Hep3B cells. Meanwhile, compound 1 showed mild neuroprotective activity against corticosterone (CORT)-induced PC12 cell damage at 10 μmol·L-1.
