Gallic Acid: A Potential Anti-Cancer Agent.
10.1007/s11655-021-3345-2
- Author:
Yuan JIANG
1
;
Jin PEI
2
;
Yan ZHENG
1
;
Yu-Jing MIAO
1
;
Bao-Zhong DUAN
3
;
Lin-Fang HUANG
4
Author Information
1. Key Laboratory of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.
2. State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
3. College of Pharmaceutical Science, Dali University, Dali, Yunnan Province, 671000, China.
4. Key Laboratory of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China. lfhuang@implad.ac.cn.
- Publication Type:Review
- Keywords:
application;
bibliometric;
cancer;
gallic acid;
tumor
- MeSH:
Adenocarcinoma/drug therapy*;
Antineoplastic Agents/therapeutic use*;
Apoptosis;
Cell Line, Tumor;
Colonic Neoplasms;
Gallic Acid/therapeutic use*;
Humans;
Male
- From:
Chinese journal of integrative medicine
2022;28(7):661-671
- CountryChina
- Language:English
-
Abstract:
Cancer is one of the most devastating diseases worldwide and definitive therapeutics for treating cancer are not yet available despite extensive research efforts. The key challenges include limiting factors connected with traditional chemotherapeutics, primarily drug resistance, low response rates, and adverse side-effects. Therefore, there is a high demand for novel anti-cancer drugs that are both potent and safe for cancer prevention and treatment. Gallic acid (GA), a natural botanic phenolic compound, can mediate various therapeutic properties that are involved in anti-inflammation, anti-obesity, and anti-cancer activities. More recently, GA has been shown to exert anti-cancer activities via several biological pathways that include migration, metastasis, apoptosis, cell cycle arrest, angiogenesis, and oncogene expression. This review discusses two aspects, one is the anti-cancer potential of GA against different types of cancer and the underlying molecular mechanisms, the other is the bibliometric analysis of GA in cancer and tumor research. The results indicated that lung cancer, prostate cancer, stomach cancer, and colon adenocarcinoma may become a hot topic in further research. Overall, this review provides evidence that GA represents a promising novel, potent, and safe anti-cancer drug candidate for treating cancer.
