Transoral robotic nasopharyngectomy for local recurrent nasopharyngeal carcinoma.
10.3760/cma.j.cn115330-20210804-00519
- VernacularTitle:经口机器人手术治疗局部复发鼻咽癌的临床研究
- Author:
Ping HAN
1
;
Fa Ya LIANG
1
;
Pei Liang LIN
1
;
Yue Jia SU
1
;
Yi Min LIU
2
;
Xiao Ming HUANG
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510280, China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou 510280, China.
2. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou 510280, China Department of Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510280, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Humans;
Male;
Middle Aged;
Nasopharyngeal Carcinoma/surgery*;
Nasopharyngeal Neoplasms/pathology*;
Neoplasm Recurrence, Local/surgery*;
Quality of Life;
Retrospective Studies;
Robotic Surgical Procedures
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2022;57(5):552-558
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the safety, efficacy, locally control and survival results of transoral Da Vinci robotic surgery for salvage treatment of locally recurrent nasopharyngeal carcinoma. Methods: This retrospective study included 33 patients with locally recurrent nasopharyngeal carcinoma (stage rT1-2, partial rT3) underwent transoral Da Vinci robotic surgery between October 2017 and January 2020. There were 20 males and 11 females, with an average age of (47.9±10.5) years. The lesions were localized in nasopharyngeal cavity in 14 cases, with extending to parapharyngeal space in 6 cases and the floor of sphenoid sinus in 13 cases. Transnasal endoscopy was used to assist surgery if necessary. SPSS 25.0 statistical software was used for statistical analysis. Results: Transoral robotic nasopharyngectomy was successfully performed in all cases without conversion to open surgery, of which 13 cases were combined with transnasal endoscopic surgery. The average operation time was (126.2±30.0) min, ranging from 90 to 180 min. The postoperative pathological margin was R0 (31 cases) and R1 (2 cases), with no tumor residue. Complications of surgery mainly included symptoms of headache, nasal dryness and velopharyngeal insufficiency without nasopharyngeal hemorrhage. Follow-up time was from 3 to 54 months. One case had tumor recurrence 11 months after operation, 1 case had ipsilateral cervical lymph node metastasis 27 months after operation, 2 cases had distant metastasis and 1 case died of nasopharyngeal hemorrhage 3 months after operation. The 1-year, 2-year and 3-year overall survival rates were 97.0%, 96.0% and 92.9%, respectively and the local recurrence free rates were 97.0%, 95.7% and 91.7%, respectively. Conclusion: Transoral robotic nasopharyngectomy is safe and feasible for local recurrent nasopharyngeal carcinoma in selected patients, with higher local control rate and quality of life.
