Incidence of gastric cancer and risk factors in Suzhou cohort.
10.3760/cma.j.cn112338-20210707-00536
- VernacularTitle:苏州队列人群的胃癌发病状况及其危险因素
- Author:
Ning Bin DAI
1
;
Xiao Yan ZHU
1
;
Lai JIANG
1
;
Yan GAO
1
;
Yu Jie HUA
2
;
Lin Chi WANG
2
;
Jin Yi ZHOU
3
;
Ming WU
3
;
Yan LU
2
Author Information
1. Biological Sample Application and Management Department, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China.
2. Chronic Non-communicable Diseases Prevention and Control Department, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China.
3. Chronic Non-communicable Diseases Prevention and Control Institute, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Child;
Cohort Studies;
Female;
Humans;
Incidence;
Male;
Proportional Hazards Models;
Prospective Studies;
Risk Factors;
Stomach Neoplasms/epidemiology*
- From:
Chinese Journal of Epidemiology
2022;43(4):452-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe gastric cancer incidence in Suzhou cohort, explore the environmental risk factors of gastric cancer in Suzhou, and provide appropriate suggestions for gastric cancer prevention and control. Methods: The participants were from the Suzhou cohort of China Kadoorie Biobank. Baseline survey was conducted from 2004 to 2008, followed by long-term follow-up until December 31, 2013. After the exclusion of those who had been previously diagnosed with peptic ulcer and malignant tumor reported at baseline survey and gastric cancer within six months after enrollment, a total of 50,136 participants were included. Cox proportional risk models were used to identify risk factors of gastric cancer and their hazard ratios in Suzhou. The effect modifications of gender on the association between risk factors and gastric cancer were analyzed. Results: In the follow-up of 7.19 years (median), 374 gastric cancers cases occurred. The standardized incidence was 94.57 per 100 000 person-years. Multivariate Cox proportional risk model analysis found that age (10 years old as a age group, HR=2.20, 95%CI: 1.92-2.53, P<0.001), current smoking (HR=1.84, 95%CI: 1.10-3.07 P=0.020), consumption of preserved vegetables weekly (HR=2.28, 95%CI: 1.28-4.07, P=0.005) and daily (HR=2.05, 95%CI: 1.16-3.61, P=0.013) were risk factors for gastric cancer. Female (HR=0.44, 95%CI: 0.25-0.76, P=0.003) and refrigerator use (10 years as a limit, HR=0.85, 95%CI: 0.74-0.97, P=0.016) were protective factors for gastric cancer. Further analysis showed that there was heterogeneity between males and females in the association between refrigerator use years and the incidence of gastric cancer (P=0.009), and there was an interaction effect between gender and refrigerator use on the incidence of gastric cancer (P=0.010). Conclusions: The incidence of gastric cancer in Suzhou cohort was high. The risk factors of gastric cancer varied. There was a synergistic interaction effect between gender and refrigerator use years on the incidence of gastric cancer.
