Correlation between HIV infection, club drug use and anal canal human papillomavirus infection in men who have sex with men in Taizhou.
10.3760/cma.j.cn112338-20210720-00570
- VernacularTitle:台州市男男性行为者HIV感染和新型毒品使用与人乳头瘤病毒感染相关分析
- Author:
Jing ZHANG
1
;
Wei Wei SHEN
2
;
Mei Yang GAO
1
;
Ying Ying DING
1
;
Na HE
1
;
Hai Jiang LIN
2
;
Xiao Xiao CHEN
2
;
Xing LIU
1
Author Information
1. Department of Epidemiology/Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
2. Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China.
- Publication Type:Journal Article
- MeSH:
Anal Canal;
Cross-Sectional Studies;
Female;
HIV Infections;
Homosexuality, Male;
Humans;
Illicit Drugs;
Male;
Papillomaviridae;
Papillomavirus Infections;
Risk Factors;
Sexual Behavior;
Sexual and Gender Minorities
- From:
Chinese Journal of Epidemiology
2022;43(3):380-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation between club drug use and anal canal human papillomavirus (HPV) infection in HIV-negative and HIV-positive men who have sex with men (MSM) in Taizhou. Methods: A cross-sectional survey was conducted in Taizhou. HIV-negative MSM were recruited by convenient sampling in voluntary counseling and testing clinics of Taizhou prefectural CDC from August 2016 to October 2017, and HIV-positive MSM were recruited through the routine follow-up and management by Taizhou prefectural CDC from August 2016 to June 2019. A face-to-face questionnaire interview was conducted to collect the information about the socio-demographic characteristics, sexual orientation, sexual behavior, club drug use and other information of the participants. Anal canal swabs were collected for HPV genotyping. The correlation between club drug use and the prevalence of HPV infection were evaluated with χ2 test and logistic regression analysis. Results: A total of 69 HIV-negative and 345 HIV-infected MSM were included. The prevalence of any type of anal canal HPV infection in HIV-negative MSM (27.5%, 19/69) was lower than that in HIV-positive MSM (66.4%, 229/345) (χ2=36.114,P<0.001). The prevalence of self-reported club drug use in HIV-negative MSM was higher (17.4%, 12/69) than that in HIV-positive MSM (7.0%, 24/345) (χ2=7.886, P=0.005). For HIV-negative MSM, the prevalence of club drug use was higher in MSM who had homosexual group sex (P=0.036); the prevalence of HPV infection was 50.0% (6/12) in club drug users and 22.8% (13/57) in non-club drug users (χ2=3.674, P=0.055). For HIV-positive MSM, the prevalence of HPV infection was 70.8% (17/24) in club drug users and 66.0% (212/321) in non-club drug users (χ2=0.230, P=0.632). Multivariable logistic regression model showed that HPV infection in MSM was positively correlated with HIV infection (OR=5.42, 95%CI: 2.92-10.06), and the association between HPV infection and club drug use (OR=1.66, 95%CI: 0.75-3.71) was not significant. Conclusions: HIV infection was positively correlated with anal canal HPV infection in MSM in Taizhou. Club drug use was positively correlated with high-risk sexual behaviors, while its association with HPV infection needs further study.
