Associations of body mass index and waist circumference with hospitalization risk of kidney stones in Chinese adults.
10.3760/cma.j.cn112338-20210311-00201
- VernacularTitle:中国成年人体质指数和腰围与肾结石住院风险的关联研究
- Author:
Han WANG
1
;
Jun Ning FAN
1
;
Can Qing YU
1
;
Yu GUO
2
;
Pei PEI
3
;
Jun Shi CHEN
4
;
Zheng Ming CHEN
5
;
Jun LYU
1
;
Li Ming LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University/Peking University Center for Public Health and Epidemic Preparedness and Response/Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing 100191, China.
2. Fuwai Hospital Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China.
3. Chinese Academy of Medical Sciences, Beijing 100730, China.
4. China National Center for Food Safety Risk Assessment, Beijing 100022, China.
5. Nuffield Department of Population Health, Center for Clinical and Epidemiological Studies/Population Health Research Unit, Medical Research Council , University of Oxford, Oxford OX3 7LF, UK.
- Publication Type:Journal Article
- MeSH:
Adult;
Body Mass Index;
Hospitalization;
Humans;
Kidney Calculi/epidemiology*;
Risk Factors;
Waist Circumference
- From:
Chinese Journal of Epidemiology
2022;43(2):154-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the associations of body mass index (BMI) and waist circumference with hospitalization risk of kidney stones in Chinese adults. Methods: This study used long-term follow-up data from China Kadoorie Biobank. After excluding participants with chronic kidney disease, cancer, and extreme BMI or waist circumference values at baseline, 502 096 participants were included in the present analysis. Cox proportional hazards regression models were used to estimate the associations of BMI and waist circumference with hospitalization risk of kidney stones. Results: During an average follow-up period of (10.7±2.2) years, 12 396 participants were hospitalized for the first time with kidney stones. Using the participants with BMI (kg/m2) of 20.5-22.4 as reference, the multivariable-adjusted HR (95%CI) for those with BMI of <18.5, 18.5-20.4, 22.5-23.9, 24.0-25.9, 26.0-27.9, 28.0-29.9, and ≥30.0 were 0.96 (0.87-1.05), 0.94 (0.88-1.00), 1.11 (1.05-1.17), 1.25 (1.18-1.32), 1.29 (1.21-1.37), 1.39 (1.28-1.50), and 1.54 (1.40-1.71), respectively. For every 1 kg/m2 increase in BMI, the HR of kidney stones hospitalization increased by 4% (HR=1.04, 95%CI: 1.04-1.05). Using the participants with waist circumference (cm) of 75.0-79.9 as reference, the multivariable-adjusted HR (95%CI) for those with waist circumference of <65.0, 65.0-69.9, 70.0-74.9, 80.0-84.9, 85.0-89.9, 90.0-94.9, and ≥95.0 were 0.82 (0.74-0.91), 0.85 (0.80-0.92), 0.95 (0.89-1.00), 1.16 (1.09-1.22), 1.22 (1.15-1.30), 1.28 (1.19-1.38), and 1.46 (1.35-1.58), respectively. For every 5 cm increase in waist circumference, the HR of kidney stones hospitalization increased by 9% (HR=1.09, 95%CI: 1.08-1.10). After mutually adjusting for BMI and waist circumference in the above models, the association between BMI and hospitalization risk of kidney stones disappeared. In contrast, the association between waist circumference and hospitalization risk of kidney stones remained unchanged. Conclusions: BMI and waist circumference were positively associated with hospitalization risk of kidney stones. The increased waist circumference was an independent risk factor for kidney stones among Chinese adults.
