Progress of molecular biology of differentiated thyroid carcinoma and its effects on diagnosis and prognosis judgement
10.3760/cma.j.cn115355-20210928-00442
- VernacularTitle:分化型甲状腺癌分子生物学研究进展及对诊断和预后判断的影响
- Author:
Yuce WEI
1
;
Di ZHANG
;
Yue CHAI
;
Mei DONG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院内科，北京 100021
- Keywords:
Thyroid neoplasms;
Molecular biology;
Diagnosis;
Prognosis
- From:
Cancer Research and Clinic
2022;34(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of thyroid cancer continues to increase, among which differentiated thyroid cancer occupies the main position. Development of molecular biology has facilitated early diagnosis and precise treatment of thyroid carcinoma, and hopefully provided potential options for certain subtypes with poor prognosis, such as radioactive iodine-refractory differentiated thyroid carcinoma. This review summarizes the gene variants of high frequency and the mechanism of such gene variants, application of molecular biological detection in clinical diagnosis, as well as the correlation of specific gene variants with clinicopathological characteristics and prognosis for differentiated thyroid carcinoma.
