Progress of γ-synuclein in tumor proliferation, invasion, migration and drug resistance

VernacularTitle:γ突触核蛋白在肿瘤细胞增殖、侵袭、迁移和化疗耐药中的研究进展
Author: Feng TANG ¹ ; Hao LONG ; Yan ZHANG ; Tingting SUN ; Wei YUAN
Author Information

1. 解放军63650部队医院五官科，乌鲁木齐　841700
Keywords: γ-synuclein; Neoplasms; Cell proliferation; Drug resistance, neoplasm
From: Cancer Research and Clinic 2022;34(2):154-157
CountryChina
Language:Chinese
Abstract: γ-synuclein (SNCG) has been extensively studied for its specific overexpression in various malignant neoplasms. Recently, SNCG has been found to be involved in multiple signaling pathways, including estrogen, AKT-mTOR, mitogen-activated protein kinase (MAPK) and microtubule regulation. SNCG has also been found to be related to the proliferation, invasion, migration and chemotherapy drug resistance of neoplasms. Therefore, SNCG is expected to be the key target of anti-tumor and improving the sensitivity of tumor cells to chemotherapeutic drugs.