Progress of osimertinib in epidermal growth factor receptor mutant non-small cell lung cancer
10.3760/cma.j.cn115355-20210326-00144
- VernacularTitle:奥希替尼在表皮生长因子受体突变非小细胞肺癌中的研究进展
- Author:
Yumeng SUN
1
;
Qingwei MENG
Author Information
1. 哈尔滨医科大学附属肿瘤医院呼吸内科，哈尔滨 150000
- Keywords:
Osimertinib;
Receptor, epidermal growth factor;
Sensitive mutation;
Rare mutation
- From:
Cancer Research and Clinic
2022;34(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
As an important tumor driver gene, epidermal growth factor receptor (EGFR) gene plays an important role in the development and progression of non-small cell lung cancer (NSCLC). As the latest generation of EGFR-tyrosine kinase inhibitor (TKI) drugs, osimertinib has brought significant therapeutic efficacies and encouraging results both in patients with sensitive EGFR mutations and patients with rare EGFR mutations. Compared with previous EGFR-TKI drugs, osimertinib has strong blood-brain barrier penetration, which can effectively prevent the occurrence of lung cancer brain metastasis. After the resistance of first and second generation of targeted drugs, osimertinib is still effective in the follow-up treatment process. This article reviews the characteristics of EGFR mutation, the action mechanism of osimertinib, and the latest progress of osimertinib in treatment of EGFR mutations in NSCLC.
