Advances in macrophage immune metabolism of systemic lupus erythematosus

VernacularTitle:巨噬细胞免疫代谢在系统性红斑狼疮中的研究进展
Author: Shanshan ZHOU ¹ ; Lin ZHOU ; Yan LIANG
Author Information

1. 海军军医大学附属长征医院检验科，上海200003
Keywords: Lupus erythematosus, Systemic; Macrophages; Immunity; Metabolism
From: Chinese Journal of Laboratory Medicine 2022;45(4):408-412
CountryChina
Language:Chinese
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of large amounts of autoantibodies and the involvement of multiple organs. The polarization imbalance and abnormal activation of macrophages are closely related to the occurrence and development of SLE, and M1 macrophages, specifically, play a pro-inflammatory role in the pathogenesis of SLE. Changes in the immune microenvironment of SLE patients would promote the metabolic reprogramming of macrophages, and induce fluctuations in sugar metabolism, lipid metabolism, and amino acid metabolism, which lead to the accumulation of intermediate metabolites that would act as inflammatory signaling molecules to aggravate the inflammatory response and cause a series of complications. Therefore, a full understanding of the metabolic process of macrophages in SLE will help elucidate the pathogenesis of SLE and lay the foundation for targeted therapy of macrophages.