Diagnostic value of glycoprotein in liver cancer
10.3760/cma.j.cn114452-20211118-00723
- VernacularTitle:糖蛋白质在肝癌中的临床诊断价值
- Author:
Ke GAO
1
;
Qiang GAO
;
Shu ZHANG
Author Information
1. 复旦大学附属中山医院肝癌研究所 癌变与侵袭原理教育部重点实验室，上海200032
- Keywords:
Liver Neoplasms;
Glycoproteins;
Diagnosis;
Tumor Markers
- From:
Chinese Journal of Laboratory Medicine
2022;45(4):332-336
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer is the fourth most common malignant tumor and the second leading cause of tumor death in China. The development of novel biomarkers for early diagnosis and treatment of liver cancer patients is important to improve the survival rate. The most common tumor biomarkers in clinical practice are glycoproteins currently. With omics technologies, the clinically significant glycoproteomics and glycomics for liver cancer diagnosis are discovered. In this article, a variety of glycobiomarkers were summarized. Methods, problems and challenges for clinical detection are posed. The relevant techniques of glycoprotein research, including high-throughput omics method and single glycoprotein detection are discussed, as well as potential liver cancer glycoprotein markers based on these techniques. The potential application of the glycoproteins in the clinical diagnosis of liver cancer is also considered.
