Application of IgG sialylation in the diagnosis and therapy of autoimmune diseases
10.3760/cma.j.cn114452-20211125-00738
- VernacularTitle:IgG唾液酸化在自身免疫疾病诊治中的应用
- Author:
Wei WANG
1
;
Chunfang GAO
Author Information
1. 上海中医药大学附属岳阳中西医结合医院临床检验实验医学中心，上海200437
- Keywords:
Autoimmune diseases;
Immunoglobulin G;
Glycosylation;
Sialic acids
- From:
Chinese Journal of Laboratory Medicine
2022;45(4):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Glycosylation is a part of the structure and function of immunoglobulin G (IgG). Sialic acid is located at the end of IgG N-glycan and regulates IgG anti-inflammatory and pro-inflammatory activities by changing the binding of IgG with fragment crystallizable gamma receptors (FcγRs) and complements. Low IgG sialylation is closely related to the occurrence, development and prognosis of autoimmune diseases and shows great potential in the field of diagnosis, monitoring and treatment, and may function as a new biomarker and therapeutic target for autoimmune diseases.
