Glycosylation: new era for diseases biomarkers
10.3760/cma.j.cn114452-20220207-00053
- VernacularTitle:糖基化：未来可期的新型疾病标志物
- Author:
Chunfang GAO
1
Author Information
1. 上海中医药大学附属岳阳中西医结合医院临床检验实验医学中心，上海 200437
- Keywords:
Glycosylation;
Glycoproteins;
Biomarker
- From:
Chinese Journal of Laboratory Medicine
2022;45(4):315-317
- CountryChina
- Language:Chinese
-
Abstract:
Glycosylation is one of the most important posttranslational modification (PTM) for proteins. Glycans of glycoproteins play pivotal effects in cell recognition, signal transduction, differentiation, proliferation and immigration. The sialylation, fucosylation and degree of branching are intimately related to the development and progression of various malignancies and autoimmune diseases. Both glycans as well as glycoprotein have become the hot targets for disease biomarker exploration and therapeutic interventions.
